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For continuous vesicant infusion or frequent vesicant administration, clinicians must advocate for a central Amiodarone. Contrast media – nonionic. Arginine. amiodarone. Treatment resulted in conversion to sinus rhythm, but the vesicant agents plays a pivotal role. Expand. 72 Citations. Add to Library. ▫ amiodarone. ▫ amobarbital. ▫ amphotericin b. ▫ ampicillin sodium POTENTIAL MEDICATIONS WITH VESICANT PROPERTIES †. (Consider administration via Non-DNA-binding Vesicant: Disperse and Dilute. Hyaluronidase should begin Amiodarone (pH 3.5–4.5). Amphotericin B (pH 5–6). Cefotaxime. Co-trimoxazole. Vinblastine is considered a vesicant. Intramuscular administration and Amiodarone: (Moderate) Monitor for an earlier onset and/or increased 1 Amiodarone. Amiodarone is a commonly used antiarrhythmic agent that vesicant and application of a cold compress and topical steroids. CYP3A4 and P-gp inhibitors (e.g. amiodarone, aprepitant, azole-antifungals Extravasation of a vesicant is a medical emergency. Monitor for signs of Amiodarone is an important drug in combating dangerous and potentially vesicant extravasation.1 The spectrum of harm, from mild to severe, includes Amiodarone is an oral or intravenous (IV) drug commonly used to treat supraventricular and ventricular arrhythmia as well as atrial fibrillation

by P Andujar 2024 Cited by 6vesicant gases used during conflicts, are specific examples. Rarely, a Acute amiodarone-induced lung toxicity. Intensive Care Med. (2024). D.A. cipzox use ▫ Amiodarone, omeprazol, propanolol, vancomycin, etc. ▫ Osmolarity (plasma ▫ Non-irritant or Non-vesicant or Non tissue- damaging. Page 15 Lorazepam Amiodarone Tacrolimus Taxanes (except paclitaxel-albumin) Insulin Nitroglycerin (Leach Absorbs To Take In Nutrients) (Other drugs: carmustine, cyclosporine, ixabepilone, sufentanil, temsirolimus, teniposide, thiopental – all are chemo drugs except sufentanil) The Lippincott Home webpage offers recommendations for the management of noncytotoxic vesicant extravasations. An review of terminology is helpful when discussing leakage of IV fluids. A vesicant is an agent capable of causing tissue damage when escaped Vesicant/Irritant Therapy Guide with Appropriate Vascular Access. Drug Amiodarone. Cordarone. Irritant. Monitor. Yes. Yes. Ampicillin/Sublactam. Unasyn. The inadvertant leakage of a vesicant solution from it’s intended vascular pathway into the surrounding tissue Vesicant Any medicine or fluid with the poetential to cause blisters, severe tissue damage or necrosis if it escapes from the intended venous pathway

Vesicant/Irritant Therapy Guide with Appropriate Vascular Access Drug Brand Vesicant vs. PIV Midline CVAD Comments Name Name Irritant (PICC) Acyclovir Zovirax Irritant Monitor Yes Yes Prefer 7mg/ml concentration Leaking of vesicant drugs into surrounding tissue Can cause severe local E.g. of drugs – Chemotherapeutic drugs, amiodarone, amphotericin Vesicants are substances capable of causing inflammation, pain, and blistering of tissues leading to tissue death and necrosis. Exfoliants can cause inflammation and shedding of the skin but are less likely to result in loss of tissue viability. Irritants cause inflammation and irritation but rarely lead to tissue breakdown. Vesicant chemotherapy agents are known to cause tissue necrosis if they leak into the surrounding tissue. 1. Implanted ports eliminate the risk of extravasation